Description
Omeflox® Eye and Ear Drops are manufactured by DCI Pharmaceuticals. The active ingredient comprised in drops is Ofloxacin, a 2nd generation antibiotic from the Fluoroquinolone (or Quinolone) family with a broad-spectrum activity.
Indications:
- bacterial eye infections (conjunctivitis, mucopurulent conjunctivitis, blepharoconjunctivitis, and blepharitis);
- bacterial ear infections (otitis externa, chronic suppurative otitis media with perforated tympanic membranes and acute otitis media in the presence of tympanostomy tubes).
Ofloxacin has been shown to be active against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Propionibacterium acnes, Enterobacter cloacae, Haemophilus influenzae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens.
Do not use Omeflox® Eye and Ear Drops to treat a viral or fungal infection in the eye or ear.
MOA (mechanism of action):
Ofloxacin is a broad-spectrum antibiotic, active against both gram-positive and gram-negative bacteria. It inhibits DNA gyrase (type II topoisomerase, and topoisomerase IV) – an enzyme crucial for separation of the replicated DNA, thereby inhibiting bacterial cell division. This results in bacteria death and elimination of the infection.
Dosage
For eye infections:
Conjunctivitis: during days 1-2 instill 1 to 2 drops every two to four hours in the treated eye(s) during first two days; during days 3-7 instill 1 to 2 drops four times daily.
Corneal ulcer: instill 1 to 2 drops in the treated eye(s) every 30 minutes, while awake (awaken at four and six hours after sleeping and instill 1 to 2 drops); during days 3-7 to 9 instill 1 to 2 drops hourly, while awake; during days 7 to 9 instill 1 to 2 drops, four times daily.
In severe infections, apply 2 drops into the treated eye(s) hourly until improvement is obtained following which treatment should be reduced.
For ear infections:
Otitis externa: 10 drops twice daily.
Suppurative otitis media with perforated tympanic membranes: 10 drops twice daily for 14 days.
Precautions:
Omeflox® Eye and Ear Drops are not intended for use in children under 1 year of age.
Prolonged use may result in a fungal infection. If superinfection occurs discontinue use and institute alternative therapy.
Omeflox® Eye and Ear Drops are for topical ophthalmic and otic use only.
Ofloxacin solution is not for injection.
Ofloxacin solution is associated with allergic reactions, even following a single dose. Discontinue using drops immediately and contact your physician at the first sign of a rash or allergic reaction.
Omeflox® Eye and Ear Drops may cause your vision to blur temporarily after you have applied them into your eye. Do not drive or operate machinery until this has worn off.
Avoid contaminating the applicator tip with eye, fingers or another source.
Patients should not wear contact lenses while using Ofloxacin solution for eye infection.
Wash your hands before using the eye drops.
Missing a dose
If you miss a dose you should instill it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.
Overdose
If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.
Storage
Store at cool room temperature, away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. Use within one month after opening a container. Keep out of the reach of children.
